Cambridge Healthtech Institute’s Inaugural
Expanding Chemical & Druggable Space
Encoded Libraries & Macrocyclics, FBDD & Lead Generation, PROTACs
June 2-4, 2020
Progress of the past decade in encoded libraries and macrocyclic peptide synthesis are enabling new types of drug-like molecules to be created and rapidly screened, which is widening the ‘base’ from which successful drugs can be found. Moreover,
the types of intracellular targets these newer chemical entities can act upon is also expanding. Disease-relevant protein-protein interactions (PPIs) and larger molecular complexes can be disrupted by these larger, yet cell-penetrable drug-like compounds.
Fragment-based drug discovery (FBDD) and other biophysical screening approaches have also provided drug leads against such non-traditional, non-enzymatic drug targets. And now one of the latest innovations in drug discovery, PROTACs, special compounds
designed against any part of the target so that upon binding of the PROTACs the target is destroyed, is expanding therapeutic possibilities even more. But how good are all these new approaches? Is theory meeting practice? Join fellow discovery chemistry
and biology colleagues to hear case studies, discuss challenges, and share refinements that remain in the newest approaches for generating tomorrow’s orally-bioavailable medicines.
Coverage will include, but is not limited to:
Encoded Libraries & Macrocyclics
- DNA-encoded library technologies
- Prosecuting hits from DEL approaches
- mRNA-encoded libraries for macrocyclic peptides
- New chemistries for macrocyclic scaffolds
Fragment-Based Drug Design (FBDD) & Lead Generation Approaches
- Innovations in fragment library design
- Case studies of growing fragments into drug leads
- Biophysical approaches (NMR, SPR, MST) for lead generation against PPIs
- Cryo-EM applied to drug lead generation
- Covalent fragments for PROTACs applications
PROTACs & Targeted Protein Degradation
- PROTACs for enabling targeted protein degradation (TPD)
- Alternatives to PROTACs (IMiDs, CIDEs, SNIPERs, and more)
- New ligases and enzymes to trigger targeted degradation
- Innovative assays and screening platforms for studying protein degraders
If you would like to submit a proposal to give a presentation at this meeting, please click here.
The deadline for priority consideration is November 22, 2019.
All proposals are subject to review by session chairpersons and/or the Scientific Advisory Committee to ensure the overall quality of the conference program. Additionally, as per Cambridge Healthtech Institute’s policy, a select number of vendors and consultants who provide products and services will be offered opportunities for podium presentation slots based on a variety of Corporate Sponsorships.
For more details on the conference, please contact:
Anjani Shah, PhD
Senior Conference Director
Cambridge Healthtech Institute
For partnering and sponsorship information, please contact:
Manager, Business Development
Joseph Vacca, M.S.
Director, Business Development